Authors: Asharani, P.V.; Serina, N.G.B.; Nurmawati, M.H.; Wu, Y.L.; Gong, Z.; Valiyaveettil, S.

Source: Journal of Nanoscience and Nanotechnology, Volume 8, Number 7, July 2008 , pp. 3603-3609(7)

Publisher: American Scientific Publishers

Abstract:

To understand the environmental impacts of carbon nanotubes (CNTs), the toxicity study was carried out with water-soluble multi-walled carbon nanotubes (MWCNTs) using zebrafish (Danio rerio) as a model system. Zebrafish embryos were treated with different concentrations of MWCNTs. Teratogenic effects were evaluated through changes in embryonic development after 24 hours post-fertilization (hpf), 48 hpf and 72 hpf. No observable effect concentration (NOEC) was at 40 μg/mL. Lowest effect concentration (LOEC) of MWCNTs which caused significant phenotypic defects in zebrafish embryo was 60 μg/mL. At concentration above 60 μg/mL, slimy mucus like coating was observed around the embryo. At high concentrations, MWCNTs was found to be involved in the apoptosis, delayed hatching and formation of abnormal spinal chords. Thus, the toxicity of multi-walled carbon nanotubes is concentration dependent.

Keywords: MWCNT; CAPPING AGENT; ZEBRAFISH; TOXICITY; HOURS POST FERTILIZATION (HPF); APOPTOSIS

Document Type: Research article

DOI: http://dx.doi.org/10.1166/jnn.2008.432

Publication date: 2008-07-01

More about this publication?

• Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
• Editorial Board
• Information for Authors
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Technology
• By this author: Asharani, P.V. ;  Serina, N.G.B. ;  Nurmawati, M.H. ;  Wu, Y.L. ;  Gong, Z. ;  Valiyaveettil, S.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers