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Kinetics of the Nanohydrogel Flattening at a Hydrophobic Interface

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Abstract:

Hydrophobitized polysaccharides were designed to form the self-assembled nanohydrogels (hydrogel nanoparticles) in the aqueous conditions. For improving their biocompatibilities, they were decorated with the biomembrane-mimetic 2-methacryloyloxyethy1 phosphory1choline (MPC) polymers. The interfacial roles of the decorated membrane-mimetic nanohydrogels were investigated by choosing MPC branched choresteryl-bearing pullulan (CHP). Tapping-mode atomic force microscopy was used to study its adsorption mechanism on the hydrophobic highly oriented pyrolytic graphite (HOPG) surface in aqueous conditions. Dynamic observation at the interfaces revealed two distinctive patterns: the immobilized nanohydrogel particles and the flatten layers. The flattening (unfolding) kinetics with and without MPC branched nanohydrogel revealed that the flattening energy was at ∼37 kBT. The flattening rate of the MPC decorated nanohydrogels was ∼1.7 times faster than that without MPC decoration, corresponding to minor reduction of the flattening activation energy.

Keywords: AFM; BIOMEMBRANE MIMETIC POLYMER; LIQUID/SOLID INTERFACE; SELF-ASSEMBLED HYDROGEL NANOPARTICLE (NANOHYDROGEL)

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2008.141

Publication date: July 1, 2008

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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