Surface Characterization of Lipid/Chitosan Nanoparticles Assemblies, Using X-Ray Photoelectron Spectroscopy and Time-of-Flight Secondary Ion Mass Spectrometry

$113.00 plus tax (Refund Policy)

Buy Article:


Chitosan/tripolyphosphate nanoparticles are promising drug delivery systems, which show excellent capacity for protein entrapment and improvement of mucosal peptide absorption. We have recently developed a new drug delivery system consisting of assemblies formed between preformed chitosan nanoparticles and phospholipids (dipalmitoylphosphatidylcholine and dimiristoylphosphatidyl-glycerol) which are endogenous to the lung. These assemblies are prepared by lipid film hydration with a nanoparticles suspension. The aim of this work was to elucidate the architecture of these structures using sensitive surface analysis techniques such as X-ray photoelectron spectroscopy and static time-of-flight secondary ion mass spectrometry, as well as to determine their physicochemical characteristics. The combination of zeta potential measurements with the results obtained by X-ray photoelectron spectroscopy and static time-of-flight secondary ion mass spectrometry, demonstrated that a complete lipid coating of the nanoparticles can be achieved using a lipid film formed by both dipalmitoylphosphatidylcholine and dimiristoylphosphatidylglycerol, this way conferring to the lipid film a strong negative charge, which favors the interaction with the positively charged nanoparticles. Therefore, the major role of electrostatic interactions as driving forces to control the organisation of the lipid/nanoparticles assemblies was clearly evident. The implications of these findings for the structural organisation of the assemblies, for their in vitro behaviour, as well as for their mechanism of formation are discussed.
More about this publication?
  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • ingentaconnect is not responsible for the content or availability of external websites
Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more