Effects of Hydrated Forms of C60 Fullerene on Amyloid -Peptide Fibrillization In Vitro and Performance of the Cognitive Task
Authors: Podolski, I. Ya.; Podlubnaya, Z. A.; Kosenko, E. A.; Mugantseva, E. A.; Makarova, E. G.; Marsagishvili, L. G.; Shpagina, M. D.; Kaminsky, Yu. G.; Andrievsky, G. V.; Klochkov, V. K.
Source: Journal of Nanoscience and Nanotechnology, Volume 7, Numbers 4-5, April/May 2007 , pp. 1479-1485(7)
Publisher: American Scientific Publishers
Abstract:It has been shown for the first time by transmission electron microscopy that the hydrated fullerene C60 inhibited the fibrillization of amyloid-25–35 peptide. The fullerene affected the amyloid-25–35 assembly, manifesting its anti-amyloidogenic capacity. Our in vivo investigations demonstrated also that a single intracerebroventricular injection of the C60 hydrated fullerene at a dose of 7.2 nmol/ventricle significantly improved the performance of the cognitive task in control rats. The intracerebroventricular injection of the C60 hydrated fullerene (3.6 nmol/ventricle) prevented the impairment of performance of the cognitive task induced by amyloid-25–35 (22.5 nmol/ventricle). The results obtained may be useful in the development of therapy of Alzheimer's disease.
Document Type: Research Article
Publication date: April 1, 2007
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