Skip to main content

Effects of Hydrated Forms of C60 Fullerene on Amyloid -Peptide Fibrillization In Vitro and Performance of the Cognitive Task

Buy Article:

$113.00 plus tax (Refund Policy)

Abstract:

It has been shown for the first time by transmission electron microscopy that the hydrated fullerene C60 inhibited the fibrillization of amyloid-25–35 peptide. The fullerene affected the amyloid-25–35 assembly, manifesting its anti-amyloidogenic capacity. Our in vivo investigations demonstrated also that a single intracerebroventricular injection of the C60 hydrated fullerene at a dose of 7.2 nmol/ventricle significantly improved the performance of the cognitive task in control rats. The intracerebroventricular injection of the C60 hydrated fullerene (3.6 nmol/ventricle) prevented the impairment of performance of the cognitive task induced by amyloid-25–35 (22.5 nmol/ventricle). The results obtained may be useful in the development of therapy of Alzheimer's disease.

Keywords: ALZHEIMER'S DISEASE; AMYLOID BETA-PEPTIDE FIBRILLIZATION; ANIMAL MODEL; COGNITIVE TASKS; HIPPOCAMPUS; HYDRATED C60 FULLERENE

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2007.330

Publication date: April 1, 2007

More about this publication?
  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • ingentaconnect is not responsible for the content or availability of external websites
asp/jnn/2007/00000007/F0020004/art00036
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more