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Effects of Hydrated Forms of C60 Fullerene on Amyloid -Peptide Fibrillization In Vitro and Performance of the Cognitive Task

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It has been shown for the first time by transmission electron microscopy that the hydrated fullerene C60 inhibited the fibrillization of amyloid-25–35 peptide. The fullerene affected the amyloid-25–35 assembly, manifesting its anti-amyloidogenic capacity. Our in vivo investigations demonstrated also that a single intracerebroventricular injection of the C60 hydrated fullerene at a dose of 7.2 nmol/ventricle significantly improved the performance of the cognitive task in control rats. The intracerebroventricular injection of the C60 hydrated fullerene (3.6 nmol/ventricle) prevented the impairment of performance of the cognitive task induced by amyloid-25–35 (22.5 nmol/ventricle). The results obtained may be useful in the development of therapy of Alzheimer's disease.
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Keywords: ALZHEIMER'S DISEASE; AMYLOID BETA-PEPTIDE FIBRILLIZATION; ANIMAL MODEL; COGNITIVE TASKS; HIPPOCAMPUS; HYDRATED C60 FULLERENE

Document Type: Research Article

Publication date: 2007-04-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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