Authors: Cho, Young-Ho; Youn, Sechan; Lee, Dong Woo

Source: Journal of Nanoscience and Nanotechnology, Volume 7, Number 11, November 2007 , pp. 4214-4219(6)

Publisher: American Scientific Publishers

Abstract:

The paper presents a couple of biofluidic devices, whose functions are inspired from biological cell concentration and deformability monitoring functions. The cell concentration monitoring chip is inspired from RBC control mechanism in kidney, performing cell concentration monitoring functions. The cell deformability chip, inspired from selective RBC destruction mechanism in spleen, performs mechanical cell deformability monitoring functions. The structures and principles of the bio-inspired chips are presented and compared with those of the biological organs. The unique features and performance characteristics of the bio-inspired chips are analyzed and verified from experimental study. The bio-inspired cell concentration monitoring chips perform flow-rate insensitive concentration measurement, while the bio-inspired cell deformability monitoring chips achieve size-independent cell deformability measurement. Common advantages of the bio-inspired chips include simple structures, digital signals and high integrability, thus making them suitable for use in integrated digital biomedical systems.

Keywords: BIO-INSPIRATION; DIGITAL BIOFLUIDIC CHIPS; CELL CONCENTRATION; CELL DEFORMABILITY; PARTICLE COUNTERS; PARTICLE CONCENTRATION; MECHANICAL DEFORMABILITY; MEMBRANE STRAIN; CELL LYSIS RATES

Document Type: Research article

DOI: http://dx.doi.org/10.1166/jnn.2007.001

Publication date: 2007-11-01

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• Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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