@article {Pierstorff:September 2007:1533-4880:2949,
	author = "Pierstorff, Erik",
	author = "Ho, Dean",
	title = "Monitoring, Diagnostic, and Therapeutic Technologies for Nanoscale Medicine",
	journal = "Journal of Nanoscience and Nanotechnology",
	volume = "7",
	year = "September 2007",
	abstract = "The advent of medically-relevant technologies forged at the interface of life science and engineering will undoubtedly play a major role in shaping the next-generation of experimental as well as clinical medicine. This review will explore the development of a suite of platform modalities that can be employed towards medical diagnostics and therapeutics. Their specific relevance and impact towards cardiovascular medicine will be realized through biotic-abiotic coalescence, or the bridging of biological materials such as cells and proteins with non-biological materials such as polymers or solid-state devices. These modalities include: (1) <I>Real-Time Cellular Interrogation Technology</I>, which enables real-time investigation, or examination of cellular signal transduction and gene expression as a response to environmental conditions; (2) <I>Diagnostic Devices</I>, which include the fabrication of micro/nano sensors for the targeting of molecules indicative of cellular disorders; and (3) <I>Therapeutics</I>, or the engineering of membrane mimetics, or biomolecule-functionalized thin films as strategies for synthetic biological regenerative medicine, as well as therapeutically-active polymers as biocompatible coatings for implants, to name a few. These approaches collectively represent a universally-applicable, and comprehensive diagnostic-treatment strategy whereby cardiovascular disorders, or medical diseases in general can be diagnosed, monitored, and fundamentally understood to unprecedented levels. In turn, these conditions can be therapeutically addressed using drug-releasing nanostructured polymers with minimal intrusion upon normal cellular behavior, or biologically-active hybrid membrane devices based upon the interface of proteins with robust biomimetic polymers.",
	pages = "2949-2968(20)",
	url = "http://www.ingentaconnect.com/content/asp/jnn/2007/00000007/00000009/art00001"
	doi = "doi:10.1166/jnn.2007.893"
}