Authors: Zhou, Jian; Zhang, Renyun; Li, Xiaomao; Gutmann, Sebastian; Lv, Gang; Wang, Xuemei

Source: Journal of Nanoscience and Nanotechnology, Volume 7, Number 8, August 2007 , pp. 2942-2947(6)

Publisher: American Scientific Publishers

Abstract:

Fe₃O₄ nanoparticles are the most commonly used magnetic materials with promising applications in biomedical and biochemical engineering. In this study, a novel application of the tetraheptylammonium capped Fe₃O₄ nanoparticles in controllable biorecognition process of anticancer drug doxorubicin through combination with external static magnetic field has been demonstrated. Our AFM and electrochemical studies illustrate that the presence of the tetraheptylammonium capped Fe₃O₄ nanoparticles could promote the binding behavior of doxorubicin to DNA. And the results of the electrochemical contact angle measurements indicate that the controllable biomolecular recognition of doxorubicin could be readily achieved by combining these functionalized Fe₃O₄ nanoparticles with changing the positions of external magnetic field.

Keywords: BIOMOLECULAR RECOGNITION; DOXORUBICIN; FE3O4 MAGNETIC NANOPARTICLES; IN SITU ELECTROCHEMICAL CONTACT ANGLE MEASUREMENT

Document Type: Short communication

DOI: http://dx.doi.org/10.1166/jnn.2007.812

Publication date: 2007-08-01

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