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QCM Detection of Oligonucleotide by Quiescent Mode and Flowing Mode

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The processes of HS-DNA immobilization and colloidal gold amplification of DNA hybridization signals were monitored by quartz crystal microbalance (QCM) in real time. The QCM detection was carried out in three cases: (1) Quiescent mode under open conditions; (2) Quiescent mode under sealed conditions; and (3) Flowing mode under sealed conditions. It was demonstrated that the stability of the QCM detection was greatly improved with the flowing mode under sealed conditions in comparison with those under the other two conditions. An increase of the frequency shift under flowing mode was found to be 57.6% in the HS-DNA immobilization process and 91.5% in the nanogold amplification process relative to the quiescent mode. The flowing mode can improve not only the stability but also the sensitivity of QCM detection.


Document Type: Short Communication


Publication date: 2007-08-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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