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Liposomes Form Nanotubules and Long Range Networks in the Presence of Electric Field

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Abstract:

Liposomes are lipid bilayer-bound micron scale structures critical to therapeutic treatments, biophysical studies, cosmetics, food, constrained volume experiments, and gene transfer. Applying an electric field to separate mixtures of liposomes played a role in their discovery and is still presently used for a variety of processes. Our group has found agreement between models of electric field-induced transport and capillary electrophoresis measurements where the liposomes are described as slightly elongated with the charged lipids migrating to form a local dipole. Here we show much more diverse structures that cannot be accounted for in these models. A variety of morphologies emerge, from individual liposomes being stretched into nanotubules several microns in length to long-range organized assemblies of liposomes over tens of microns. Based in this result, existing theories for electromigration of soft particles need to be re-addressed. Also, the formation of nanoscale lipid tubules suggests that unique structures for bionanoengineering can be fabricated. Much higher intrinsic fields than those applied here are observed in biology that suggests mechanical electrostatic interaction may play role in shape and function of individual biological membranes and networks of membrane-bound structures.

Keywords: BIONANOTUBULES; ELECTRIC FIELD; IMAGING; LIPOSOMES; NANOTUBULES; SOLUTION

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2007.646

Publication date: July 1, 2007

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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