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Selective Cell Spreading, Proliferation, and Orientation on Micropatterned Gel Surfaces

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Abstract:

Hydrogel micropatterns of 10 ∼ 200 m in width were introduced during the polymerization of 2-acrylamido-2-methyl-propane sulfonic acid sodium salt (NaAMPS)on the surface of polyacrylamide (PAAm)gel. Behaviors of endothelial cells on the micropatterned PNaAMPS/PAAm gel surfaces were studied. Cells selectively proliferate on micropatterned PNaAMPS surface but not on PAAm surface, which requires no modification with any cell adhesive proteins or peptides. We found that decrease of the width of the micropatterns could increase the degree of anisotropic spreading of cells and the degree of cell orientation. These results demonstrated that the topographical micropatterns of hydrogel could control cell behaviors.

Keywords: CELL PROLIFERATION; HYDROGEL; MICROFABRICATION; PATTERNING

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2007.517

Publication date: 2007-03-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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