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Detection of Influenza Virus Hemagglutinin with Randomly Immobilized Anti-Hemagglutinin Antibody on a Carbon Nanotube Sensor

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Abstract:

Carbon nanotube sensors were capable of detecting hemagglutinin binding to anti-hemagglutinin antibody immobilized on the sensor. The carbon nanotube sensors were fabricated by chemical vapor deposition method and it showed field effect transistor property. Anti-hemagglutinin antibody was immobilized by cross-linking on the reverse surface of the carbon nanotube sensor. The current between the source and the drain was measured after incubation of various concentration of hemagglutinin antigen with immobilized anti-hemagglutinin antibody. IVgate curve was obtained by plotting the current as a function of the potential applied to the back gate. The IVgate curve showed a positive shift in a manner dependent on the hemagglutinin antigen concentration after immobilization of anti-hemagglutinin while no shift was observed without immobilization of anti-hemagglutinin antibody on the surface. The sensitivity of the CNT sensor was higher than that of the QCM method even without controlling the orientation of the anti-hemagglutinin antibody. This method constitutes a new tool to analyze interactions among biomolecules on a substrate.

Keywords: CARBON NANOTUBE SENSOR; HEMAGGLUTININ; QUARTZ-CRYSTAL MICROBALANCE (QCM)

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2007.512

Publication date: March 1, 2007

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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