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Material Design of Bioabsorbable Inorganic/Organic Composites for Bone Regeneration

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Abstract:

Two new bioabsorbable inorganic/organic composite materials were developed for bone regeneration. One material used was -TCP/PLGC in which poly(L-lactide-co-glycolide-co--caprolactone) and -tricalcium phosphate were used as the matrix and filler, respectively. The other material used was HAp/Col—a soft nanocomposite of hydroxyapatite and type I collagen. Using these composites, two bone implants were designed. The efficacy of these implants was investigated by applying them to the critical-sized bone defects that were created in the canine tibia. Although no tissue engineering techniques such as application of growth factors or stem cells was utilized, successful healing was observed. These results suggested that bone regeneration in the critical-sized defects is possible without the use of growth factors or stem cells if the materials and the bone implants are suitably designed.

Keywords: BIOABSORBABLE MATERIALS; BONE REGENERATION; COLLAGEN; HYDROXYAPATITE; L-LACTIC ACID

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2007.502

Publication date: March 1, 2007

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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