Application of Oligonucleotide as a Template for the Assembly of Nucleoamphiphile Bearing Azobenzene at the Air–Water Interface
In order to assemble amphiphilic adenine having azobenzene, C12AzoC5Ade (AzoAde), at the air–water interface based on the molecular recognition of DNA, we prepared aqueous linear oligothymidylic acids, dT n (n = 4, 6, 8, 10, 30), subphase as templates. Surface pressure–area (π−A) isotherms and UV-Vis reflection absorption spectra of AzoAde were measured to investigate the effect of chain length of the oligothymidylic acid on the molecular recognition by forming a complementary A-T base pair. It was showed that AzoAde did not form a stable monolayer on the dT4 subphase and remained monomeric state. While AzoAde provided expanded monolayers and formed J-aggregates of azobenzene moieties on the dT n (n > 4) subphases even at the low molecular density. We also investigated the molecular recognition of template oligonucleotides by comparing dT30 with dA30, indicating that AzoAde had not a specific interaction with dA30 at the air–water interface due to base mismatching. The AzoAde monolayer on the dA30 subphase gave H-aggregate from monomeric state by compressing it. On the other hand, it remained J-aggregated state on dT30 subphase regardless of compression. It was, therefore, suggested that the linear oligothymidylic acids, dT n (n > 4), acted as templates for assembling AzoAde at the air–water interface.
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Document Type: Research Article
Publication date: 01 March 2007
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