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Application of Oligonucleotide as a Template for the Assembly of Nucleoamphiphile Bearing Azobenzene at the Air–Water Interface

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Abstract:

In order to assemble amphiphilic adenine having azobenzene, C12AzoC5Ade (AzoAde), at the air–water interface based on the molecular recognition of DNA, we prepared aqueous linear oligothymidylic acids, dTn (n = 4, 6, 8, 10, 30), subphase as templates. Surface pressure–area (A) isotherms and UV-Vis reflection absorption spectra of AzoAde were measured to investigate the effect of chain length of the oligothymidylic acid on the molecular recognition by forming a complementary A-T base pair. It was showed that AzoAde did not form a stable monolayer on the dT4 subphase and remained monomeric state. While AzoAde provided expanded monolayers and formed J-aggregates of azobenzene moieties on the dTn (n > 4) subphases even at the low molecular density. We also investigated the molecular recognition of template oligonucleotides by comparing dT30 with dA30, indicating that AzoAde had not a specific interaction with dA30 at the air–water interface due to base mismatching. The AzoAde monolayer on the dA30 subphase gave H-aggregate from monomeric state by compressing it. On the other hand, it remained J-aggregated state on dT30 subphase regardless of compression. It was, therefore, suggested that the linear oligothymidylic acids, dTn (n > 4), acted as templates for assembling AzoAde at the air–water interface.

Keywords: AZOBENZENE; BASE PAIR; DNA; J-AGGREGATE; OLIGONUCLEOTIDE; SELF-ASSEMBLY

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2007.522

Publication date: March 1, 2007

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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