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Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.

Publisher: American Scientific Publishers

Volume 6, Numbers 9-10, September/October 2006
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Preface

A Special Issue on Nanotechnology in Advanced Drug Delivery
pp. i-i(1)
Author: Ravi Kumar, M.N.V.

Reviews

Polymeric Nanofibers as Novel Carriers for the Delivery of Therapeutic Molecules
pp. 2591-2607(17)
Authors: Kumbar, Sangamesh G.; Nair, Lakshmi S.; Bhattacharyya, Subhabrata; Laurencin, Cato T.

Polymer-Based Nanoparticles for the Delivery of Nucleoside Analogues
pp. 2608-2617(10)
Authors: Hillaireau, Hervé; Le Doan, Trung; Couvreur, Patrick

Arsonoliposomes: Novel Nanosized Arsenic-Containing Vesicles for Drug Delivery
pp. 2618-2637(20)
Authors: Fatouros, Dimitris G.; Ioannou, Panayiotis V.; Antimisiaris, Sophia G.

Polymeric Nanostructures for Drug Delivery Applications Based on Pluronic Copolymer Systems
pp. 2638-2650(13)
Authors: Xiong, X.Y.; Tam, K.C.; Gan, L.H.

Nanoparticles for Cellular Drug Delivery: Mechanisms and Factors Influencing Delivery
pp. 2651-2663(13)
Authors: Chavanpatil, Mahesh D.; Khdair, Ayman; Panyam, Jayanth

Nanoparticles for Drug Delivery: Review of the Formulation and Process Difficulties Illustrated by the Emulsion-Diffusion Process
pp. 2664-2681(18)
Authors: Moinard-Checot, D.; Chevalier, Y.; Briançon, S.; Fessi, H.; Guinebretière, S.

Biodegradable Nanomats Produced by Electrospinning: Expanding Multifunctionality and Potential for Tissue Engineering
pp. 2693-2711(19)
Authors: Ashammakhi, N.; Ndreu, A.; Piras, A.; Nikkola, L.; Sindelar, T.; Ylikauppila, H.; Harlin, A.; Chiellini, E.; Hasirci, V.; Redl, H.

The Blood-Brain Barrier and Brain Drug Delivery
pp. 2712-2735(24)
Authors: Koziara, J.M.; Lockman, P.R.; Allen, D.D.; Mumper, R.J.

Nanotechnologies in Protein Delivery
pp. 2736-2753(18)
Authors: Salmaso, Stefano; Bersani, Sara; Semenzato, Alessandra; Caliceti, Paolo

Management of Cardiovascular Diseases with Micro Systems and Nanotechnology
pp. 2754-2761(8)
Authors: Kong, L.X.; Peng, Z.; Sugumar, D.

Medical Applications of Magnetic Nanoparticles
pp. 2762-2768(7)
Authors: Alexiou, C.; Jurgons, R.; Seliger, C.; Iro, H.

Pharmacytes: An Ideal Vehicle for Targeted Drug Delivery
pp. 2769-2775(7)
Author: Freitas, Robert A.

Research Articles

The Influence of Physicochemical Parameters on the Efficacy of Non-Viral DNA Transfection Complexes: A Comparative Study
pp. 2776-2782(7)
Authors: Kneuer, Carsten; Ehrhardt, Carsten; Bakowsky, Heike; Ravi Kumar, M.N.V.; Oberle, Volker; Lehr, Claus M.; Hoekstra, Dick; Bakowsky, Udo

Receptor-Mediated Gene Delivery into Antigen Presenting Cells Using Mannosylated Chitosan/DNA Nanoparticles
pp. 2796-2803(8)
Authors: Kim, Tae Hee; Nah, Jae Woon; Cho, Myung-Haing; Park, Tae Gwan; Cho, Chong Su

Preparation and Characterization of Thermosensitive Submicron Particles for Gene Delivery
pp. 2804-2810(7)
Authors: Özdemir, Nalan; Tuncel, Ali; Kang, Myungchan; Denkbş, Emir Baki

siRNA Drug Delivery by Biodegradable Polymeric Nanoparticles
pp. 2821-2828(8)
Authors: Yuan, Xudong; Li, Ling; Rathinavelu, Appu; Hao, Jinsong; Narasimhan, Madhusudhanan; He, Matthew; Heitlage, Viviene; Tam, Linda; Viqar, Sana; Salehi, Mojgan

Uptake and Biocompatibility of Functionalized Poly(vinylalcohol) Coated Superparamagnetic Maghemite Nanoparticles by Synoviocytes In Vitro
pp. 2829-2840(12)
Authors: Schulze, Katja; Koch, Annette; Petri-Fink, Alke; Steitz, Benedikt; Kamau, Sarah; Hottiger, Michael; Hilbe, Monika; Vaughan, Lloyd; Hofmann, Margarethe; Hofmann, Heinrich; Von Rechenberg, Brigitte

Gene Expression in Synovial Membrane Cells After Intraarticular Delivery of Plasmid-Linked Superparamagnetic Iron Oxide Particles—A Preliminary Study in Sheep
pp. 2841-2852(12)
Authors: Galuppo, Larry D.; Kamau, Sarah W.; Steitz, Benedikt; Hassa, Paul O.; Hilbe, Monika; Vaughan, Lloyd; Koch, Sabine; Fink-Petri, Alke; Hofman, Margarethe; Hofman, Heinrich; Hottiger, Michael O.; von Rechenberg, Brigitte

Liver Targeting of Plasmid DNA with a Cationized Pullulan for Tumor Suppression
pp. 2853-2859(7)
Authors: Jo, Jun-ichiro; Yamamoto, Masaya; Matsumoto, Kunio; Nakamura, Toshikazu; Tabata, Yasuhiko

Folate Receptor-Mediated Cancer Cell Specific Gene Delivery Using Folic Acid-Conjugated Oligochitosans
pp. 2860-2866(7)
Authors: Lee, Dongwon; Lockey, Richard; Mohapatra, Shyam

A Novel Method for the Preparation of Nanoaggregates of Methoxy Polyethyleneglycol Linked Chitosan
pp. 2867-2873(7)
Authors: Kulkarni, Anandrao R.; Lin, Yu-Hsin; Liang, Hsiang-Fa; Chang, Wei-Chun; Hsiao, Wesley Wei-Wen; Sung, Hsing-Wen

Preparation and Characterization of Insulin Nanoparticles Employing Chitosan and Poly(methylmethacrylate/methylmethacrylic acid) Copolymer
pp. 2874-2886(13)
Authors: Li, Ming-Guang; Lu, Wan-Liang; Wang, Jian-Cheng; Zhang, Xuan; Zhang, Hua; Wang, Xue-Qing; Wu, Cui-Shuan; Zhang, Qiang

Development of Phosphorylated Glucomannan-Coated Chitosan Nanoparticles as Nanocarriers for Protein Delivery
pp. 2887-2895(9)
Authors: Cuña, M.; Alonso-Sande, M.; Remuñán-López, C.; Pivel, J.P.; Alonso-Lebrero, J.L.; Alonso, M.J.

Thermosensitive Nanocontainers Prepared from Poly(N-isopropylacrylamide-co-N-(hydroxylmethyl)acrylamide)-g-Poly(lactide)
pp. 2896-2901(6)
Authors: Zhang, Yan; Yang, Wuli; Wang, Changchun; Wu, Wei; Fu, Shoukuan

Characterizing Poly(ε-caprolactone)-b-Chitooligosaccharide-b-Poly(ethylene glycol) (PCP) Copolymer Micelles for Doxorubicin (DOX) Delivery: Effects of Crosslinked of Amine Groups
pp. 2902-2911(10)
Authors: Chung, Tze-Wen; Liu, Der-Zen; Hsieh, Jui-Hsiang; Fan, Xian-Chan; Yang, Jean-Dean; Chen, Jui-Hsiang

Chitosan Surface-Modified Hydroxycamptothecin Loaded Nanoparticles with Enhanced Transport Across Caco-2 Cell Monolayer
pp. 2912-2920(9)
Authors: Zhang, Leyang; Sun, Minjie; Guo, Rui; Jiang, Zhiping; Liu, Yun; Jiang, Xiqun; Yang, Changzheng

Effect of Hydroxyapatite Nanoparticles on Ibuprofen Release from Carboxymethyl-Hexanoyl Chitosan/O-Hexanoyl Chitosan Hydrogel
pp. 2929-2935(7)
Authors: Liu, Tse-Ying; Liu, Ting-Yu; Chen, San-Yuan; Chen, Shian-Chuan; Liu, Dean-Mo

Thymopentin-Loaded pH-Sensitive Chitosan Nanoparticles for Oral Administration: Preparation, Characterization, and Pharmacodynamics
pp. 2936-2944(9)
Authors: Zheng, Ai-Ping; Wang, Jian-Cheng; Lu, Wan-Liang; Zhang, Xuan; Zhang, Hua; Wang, Xue-Qing; Zhang, Qiang

Oral Administration of Liposomal Insulin
pp. 2945-2949(5)
Authors: Değim, I. Tuncer; Gümüşel, Bülent; Değim, Zelihagül; Özçelikay, Tanju; Tay, Aydin; Güner, Şahika

Development and Evaluation of Emulsion-Liposome Blends for Resveratrol Delivery
pp. 2950-2958(9)
Authors: Hung, Chi-Feng; Chen, Jan-Kan; Liao, Mei-Hui; Lo, Huey-Ming; Fang, Jia-You

Transport Characteristics of Wheat Germ Agglutinin-Modified Insulin-Liposomes and Solid Lipid Nanoparticles in a Perfused Rat Intestinal Model
pp. 2959-2966(8)
Authors: Zhang, Na; Ping, Qineng; Huang, Guihua; Han, Xiuzhen; Cheng, Yanna; Xu, Wenfang

Preparation, Characterization and In Vivo Studies of Proliposomes Containing Cyclosporine A
pp. 2967-2973(7)
Authors: Shah, Neha M.; Parikh, Jolly; Namdeo, Alok; Subramanian, N.; Bhowmick, Subhash

Arsonoliposome Interaction with Thiols: Effect of Pegylation and Arsonolipid Content of Arsonoliposomes on Their Integrity During Incubation in Glutathione
pp. 2974-2978(5)
Authors: Haikou, Maria N.; Zagana, Paraskevi; Ioannou, Panayiotis V.; Antimisiaris, Sophia G.

Photostabilization of 1,4-Dihydropyridine Antihypertensives by Incorporation into β-Cyclodextrin and Liposomes
pp. 2979-2985(7)
Authors: Ragno, G.; Risoli, A.; Ioele, G.; Cione, E.; De Luca, M.

Development and Comparative Anti-Microbial Evaluation of Lipid Nanoparticles and Nanoemulsion of Polymyxin B
pp. 2986-2990(5)
Authors: Pattani, A.S.; Mandawgade, S.D.; Patravale, Vandana B.

Methotrexate Loaded Solid Lipid Nanoparticles (SLN) for Effective Treatment of Carcinoma
pp. 2991-2995(5)
Authors: Ruckmani, K.; Sivakumar, M.; Ganeshkumar, P.A.

Camptothecin in Sterically Stabilized Phospholipid Nano-Micelles: A Novel Solvent pH Change Solubilization Method
pp. 2996-3000(5)
Authors: Koo, Otilia M.Y.; Rubinstein, Israel; Onyuksel, Hayat

Nano-Liposomal Dry Powder Inhaler of Amiloride Hydrochloride
pp. 3001-3009(9)
Authors: Chougule, Mahavir Bhupal; Padhi, Bijay Kumar; Misra, Ambikanandan

Effect of PEGylation on the Stability of Liposomes During Nebulisation and in Lung Surfactant
pp. 3010-3016(7)
Authors: Anabousi, Samah; Kleemann, Elke; Bakowsky, Udo; Kissel, Thomas; Schmehl, Thomas; Gessler, Tobias; Seeger, Werner; Lehr, Claus-Michael; Ehrhardt, Carsten

Physicochemical and Drug Delivery Aspects of Lipid-Based Liquid Crystalline Nanoparticles: A Case Study of Intravenously Administered Propofol
pp. 3017-3024(8)
Authors: Johnsson, Markus; Barauskas, Justas; Norlin, Andreas; Tiberg, Fredrik

Liposome Size Analysis by Dynamic/Static Light Scattering upon Size Exclusion-/Field Flow-Fractionation
pp. 3025-3031(7)
Authors: Hupfeld, Stefan; Holsæter, Ann Mari; Skar, Merete; Frantzen, Christer B.; Brandl, Martin

Physical Stability and Lyophilization of Poly(ε-caprolactone)-b-Poly(ethyleneglycol)-b-Poly(ε-caprolactone) Micelles
pp. 3032-3039(8)
Authors: Hu, Yong; Ding, Yin; Li, Yuan; Jiang, Xiqun; Yang, Changzheng; Yang, Yonghua

Bioerodible Polymeric Nanoparticles for Targeted Delivery of Proteic Drugs
pp. 3040-3047(8)
Authors: Chiellini, Elisabetta E.; Chiellini, Federica; Solaro, Roberto

Nanoparticles made of Fluorescence-Labelled Poly(L-lactide-co-glycolide): Preparation, Stability, and Biocompatibility
pp. 3048-3056(9)
Authors: Weiss, Barbara; Schaefer, Ulrich F.; Zapp, Josef; Lamprecht, Alf; Stallmach, Andreas; Lehr, Claus-Michael

Development of Praziquantel-Loaded PLGA Nanoparticles and Evaluation of Intestinal Permeation by the Everted Gut Sac Model
pp. 3057-3061(5)
Authors: Mainardes, Rubiana Mara.; Chaud, Marco Vinícius; Gremião, Maria Palmira Daflon; Evangelista, Raul Cesar

Intracellular Accumulation and Cytotoxicity of Doxorubicin with Different Pharmaceutical Formulations in Human Cancer Cell Lines
pp. 3062-3069(8)
Authors: Serpe, Loredana; Guido, Marilena; Canaparo, Roberto; Muntoni, Elisabetta; Cavalli, Roberta; Panzanelli, Patrizia; Pepa, Carlo Della; Bargoni, Alessandro; Mauro, Alessandro; Gasco, Maria Rosa; Eandi, Mario; Zara, Gian Paolo

Polymeric Nanoparticles as Drug controlled Release Systems: A New Formulation Strategy for Drugs with Small or Large Molecular Weight
pp. 3070-3079(10)
Authors: Leo, Eliana; Scatturin, Angelo; Vighi, Eleonora; Dalpiaz, Alessandro

Poly(lactide-co-glycolide)-Methoxy-Poly(ethylene glycol) Nanoparticles: Drug Loading and Release Properties
pp. 3080-3086(7)
Authors: Katsikogianni, Georgia; Avgoustakis, Konstantinos

Intracellular Delivery of Cysteine Protease Inhibitor Cystatin by Polymeric Nanoparticles
pp. 3087-3094(8)
Authors: Cegnar, Mateja; Kos, Janko; Kristl, Julijana

Characterization of Polymeric Micelles for Pulmonary Delivery of Beclomethasone Dipropionate
pp. 3095-3101(7)
Authors: Gaber, Nazar Noureen; Darwis, Yusrida; Peh, Kok-Khiang; Tan, Yvonne Tze-Fung

Bioadhesive Properties of Poly(alkylcyanoacrylate) Nanoparticles Coated with Polysaccharide
pp. 3102-3109(8)
Authors: Bertholon, Isabelle; Ponchel, Gilles; Labarre, Denis; Couvreur, Patrick; Vauthier, Christine

Freeze-Drying of Low Molecular Weight Poly(L-lactic acid) Nanoparticles: Effect of Cryo- and Lyoprotectants
pp. 3110-3117(8)
Authors: Hirsjärvi, Samuli; Peltonen, Leena; Kainu, Laura; Hirvonen, Jouni

Lyoprotected Nanosphere Formulations for Paclitaxel Controlled Delivery
pp. 3118-3125(8)
Authors: Musumeci, T.; Vicari, L.; Ventura, C.A.; Gulisano, M.; Pignatello, R.; Puglisi, G.

Concentration Dependent Structural Ordering of Poloxamine 908 on Polystyrene Nanoparticles and Their Modulatory Role on Complement Consumption
pp. 3126-3133(8)
Authors: Al-Hanbali, O.; Rutt, K.J.; Sarker, D.K.; Hunter, A.C.; Moghimi, S.M.

Evaluation of the Enhanced Oral Effect of Omapatrilat-Monolein Nanoparticles Prepared by the Emulsification-Diffusion Method
pp. 3134-3138(5)
Authors: Tamayo-Esquivel, D.; Ganem-Quintanar, A.; Martínez, A.L.; Navarrete-Rodríguez, M.; Rodríguez-Romo, S.; Quintanar-Guerrero, D.

Porous Hollow Silica Nanoparticles as Carriers for Controlled Delivery of Ibuprofen to Small Intestine
pp. 3139-3144(6)
Authors: Wen, Li-Xiong; Ding, Hao-Min; Wang, Jie-Xin; Chen, Jian-Feng

New Method for the Effective Production of Ultrafine Drug Nanocrystals
pp. 3145-3153(9)
Authors: Möschwitzer, Jan; Müller, Rainer H.

Physico-Chemical Characterization and In Vivo Evaluation of Indomethacin Ethyl Ester-Loaded Nanocapsules by PCS, TEM, SAXS, Interfacial Alkaline Hydrolysis and Antiedematogenic Activity
pp. 3154-3162(9)
Authors: Cruz, Letícia; Schaffazick, Scheila R.; Costa, Teresa Dalla; Soares, Leonardo U.; Mezzalira, Graziela; da Silveira, Nádya P.; Schapoval, Elfrides E.S.; Pohlmann, Adriana R.; Guterres, Sílvia S.

Gliadin Characterization by Sans and Gliadin Nanoparticle Growth Modelization
pp. 3171-3178(8)
Authors: Orecchioni, Anne-Marie; Duclairoir, Cécile; Renard, Denis; Nakache, Evelyne

Drug Solubilization and Delivery from Cyclodextrin-Pluronic Aggregates
pp. 3179-3186(8)
Authors: Rodriguez-Perez, A.I.; Rodriguez-Tenreiro, C.; Alvarez-Lorenzo, C.; Concheiro, A.; Torres-Labandeira, J.J.

Stability Studies on Colloidal Suspensions of Polyurethane Nanocapsules
pp. 3187-3192(6)
Authors: Bouchemal, K.; Briançon, S.; Couenne, F.; Fessi, H.; Tayakout, M.

Surface-Modified and Conventional Nanocapsules as Novel Formulations for Parenteral Delivery of Halofantrine
pp. 3193-3202(10)
Authors: Mosqueira, Vanessa Carla Furtado; Legrand, Philippe; Barratt, Gillian

Bioadhesive Mannosylated Nanoparticles for Oral Drug Delivery
pp. 3203-3209(7)
Authors: Salman, Hesham H.; Gamazo, Carlos; Campanero, Miguel A.; Irache, Juan M.

Controlled Drug Delivery System Based on Magnetic Hollow Spheres/Polyelectrolyte Multilayer Core-Shell Structure
pp. 3210-3214(5)
Authors: Zhang, YanQi; Li, LinLin; Tang, Fangqiong; Ren, Jun

Improved Oral Delivery of Paclitaxel Following Administration in Nanoemulsion Formulations
pp. 3215-3221(7)
Authors: Tiwari, Sandip B.; Amiji, Mansoor M.

Quantification of Magnetic Nanoparticles by Magnetorelaxometry and Comparison to Histology After Magnetic Drug Targeting
pp. 3222-3225(4)
Authors: Wiekhorst, F.; Seliger, C.; Jurgons, R.; Steinhoff, U.; Eberbeck, D.; Trahms, L.; Alexiou, C.

Nanospheres of a Bisphosphonate Attenuate Intimal Hyperplasia
pp. 3226-3234(9)
Authors: Cohen-Sela, Einat; Dangoor, David; Epstein, Hila; Gati, Irith; Danenberg, Haim D.; Golomb, Gershon; Gao, Jianchuan

Design and Evaluation of a Self-Adhesive Naproxen-Loaded Film Prepared from a Nanoparticle Dispersion
pp. 3235-3241(7)
Authors: Ganem-Quintanar, Adriana; Silva-Álvarez, Marlene; Álvarez-Román, Rocío; Casas-Alancaster, Norma; Cázares-Delgadillo, Jennyfer; Quintanar-Guerrero, David

Nanoparticles from Polylactide and Polyether Block Copolymers: Formation, Properties, Encapsulation, and Release of Pyrene—Fluorescent Model of Hydrophobic Drug
pp. 3242-3251(10)
Authors: Slomkowski, Stanislaw; Gadzinowski, Mariusz; Sosnowski, Stanislaw; Radomska-Galant, Izabela; Pucci, Andrea; De Vita, Cinzia; Ciardelli, Francesco

Nanoparticle Multilayers: Surface Modification of Photosensitive Drug Microparticles for Increased Stability and In Vitro Bioavailability
pp. 3252-3260(9)
Authors: Li, Ning; Kommireddy, Dinesh S.; Lvov, Yuri; Liebenberg, Wilna; Tiedt, Louwrens R.; De Villiers, Melgardt M.

Systemic Distribution and Elimination of Plain and with Cy3.5 Functionalized Poly(vinyl alcohol) Coated Superparamagnetic Maghemite Nanoparticles After Intraarticular Injection in Sheep In Vivo
pp. 3261-3268(8)
Authors: Hellstern, Daniel; Schulze, Katja; Schöpf, Bernhard; Petri-Fink, Alke; Steitz, Benedikt; Kamau, Sarah; Hilbe, Monika; Koch-Schneidemann, Sabine; Vaughan, Lloyd; Hottiger, Michael; Hofmann, Margarethe; Hofmann, Heinrich; von Rechenberg, Brigitte

Novel Drug Delivery System by Surface Modified Magnetic Nanoparticles
pp. 3269-3276(8)
Authors: Takeda, Shin-Ichi; Terazono, Bungo; Mishima, Fumihito; Nakagami, Hironori; Nishijima, Shigehiro; Kaneda, Yasufumi

Molecular Electrostatic Potentials in the Design of Dendrimers for the Delivery of Glitazones
pp. 3277-3282(6)
Authors: Bharatam, Prasad V.; Sundriyal, Sandeep

Development of a Novel Vaccine Delivery System Based on Gantrez Nanoparticles
pp. 3283-3289(7)
Authors: Gómez, Sara; Gamazo, Carlos; Roman, Beatriz San; Vauthier, Christine; Ferrer, Marta; Irache, Juan M.

Electrospun Multifunctional Diclofenac Sodium Releasing Nanoscaffold
pp. 3290-3295(6)
Authors: Nikkola, L.; Seppälä, J.; Harlin, A.; Ndreu, A.; Ashammakhi, N.

Nanocarriers with Gentamicin to Treat Intracellular Pathogens
pp. 3296-3302(7)
Authors: Lecaroz, C.; Gamazo, C.; Blanco-Prieto, M.J.

Human Vascular Endothelial Cells in Primary Cell Culture for the Evaluation of Nanoparticle Bioadhesion
pp. 3303-3309(7)
Authors: Löhbach, Christoph; Neumann, Dirk; Lehr, Claus-Michael; Lamprecht, Alf

Development of Diclofenac Sodium Releasing Bio-Erodible Polymeric Nanomats
pp. 3310-3320(11)
Authors: Piras, A.M.; Nikkola, L.; Chiellini, F.; Ashammakhi, N.; Chiellini, E.

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