Skip to main content

Supramolecular Assembled Nanostructure Containing Cubic Silsesquioxane in Aqueous Solution

Buy Article:

$113.00 plus tax (Refund Policy)


Micellization and aggregation behavior of amphiphilic cubic silsesquioxane-poly(ethylene oxide) (CSSQ-PEO) in aqueous solution was studied by Dynamic and Static Light Scattering (DLS and SLS), and Transmission Electron Microscopy (TEM). The effects of CSSQ-PEO concentration and temperature on particle size were also investigated. Above the critical aggregation concentration (CAC), a combination of unassociated single micelle and micellar aggregates is observed up to a certain level of CSSQ-PEO concentration as determined by DLS and TEM studies. The size of unassociated single micelles are found to be independent of CSSQ-PEO concentration while that of the micellar aggregates become larger at higher concentration due to the aggregation growth. Both studies revealed that a small CSSQ core is surrounded by PEO corona and found self-assembled nanostructure of CSSQ-PEO in aqueous solution. The molecular weight of micellar aggregates (Mw, agg), radius of gyration (Rg), and apparent aggregation number (Nagg) were evaluated by SLS measurement. The decrease in the particle size (described by hydrodynamic diameter: Dh) upon increasing temperature was observed because of the diminishing hydrophilicity of PEO. Surprisingly, Rg is also decreased at higher temperature assuming the dissociation of micellar aggregates by repulsive forces due to the crowding effect. The encapsulation property of CSSQ-PEO to model drug has also been studied. Our preliminary results from DLS and TEM studies showed the formation of CSSQ-PEO nanospheres containing drug in aqueous solution. The size of the drug loaded CSSQ-PEO nanospheres are found to be larger (250–300 nm) than that of the core-corona CSSQ-PEO micellar aggregates (∼180 nm) in dilute aqueous solution.


Document Type: Research Article


Publication date: 2006-12-01

More about this publication?
  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more