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Adhesion and Proliferation of Fibroblasts on Cluster-Assembled Nanostructured Carbon Films: The Role of Surface Morphology

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Abstract:

We have investigated the influence on adhesion and proliferation of NIH 3T3 fibroblasts of the surface morphology of cluster assembled carbon films deposited by Supersonic Cluster Beam Deposition. Nanostructured carbon films exhibit a multi-scale morphology, which resembles the surface structure of the extracellular matrix, and possess a high specific area, while being relatively smooth at all scales. Correlations between measured morphological parameters and adaptive cell response have been brought out. High specific area and smoothness appear to conceivably favour both the early attachment of plated cells and the long-term survival of adherent cells. Moreover, nanostructured carbon films affect the cells morphology as well as the extension and the number of the focal contacts.

Keywords: ATOMIC FORCE MICROSCOPY; CELL-SUBSTRATE INTERACTIONS; FOCAL ADHESIONS; NANOSTRUCTURED FILMS; SUBSTRATE TOPOGRAPHY

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2006.619

Publication date: 2006-12-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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