Detection of Tumor Markers Using Single-Walled Carbon Nanotube Field Effect Transistors

Authors: Park, Dong-Won; Kim, Yo-Han; Kim, Beom Soo; So, Hye-Mi; Won, Keehoon; Lee, Jeong-O; Kong, Ki-Jeong; Chang, Hyunju

Source: Journal of Nanoscience and Nanotechnology, Volume 6, Number 11, November 2006 , pp. 3499-3502(4)

Publisher: American Scientific Publishers

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Abstract:

We have developed a biosensor capable of detecting carcinoembryonic antigen (CEA) markers using single-walled carbon nanotube field effect transistors (SWNT-FETs). These SWNT-FETs were fabricated using nanotubes produced by a patterned catalyst growth technique, where the top contact electrodes were generated using conventional photolithography. For biosensor applications, SU-8 negative photoresist patterns were used as an insulation layer. CEA antibodies were employed as recognition elements to specific tumor markers, and were successfully immobilized on the sides of a single-walled carbon nanotube using CDI-Tween 20 linking molecules. The binding of tumor markers to these antibody-functionalized SWNT-FETs was then monitored continuously during exposure to dilute CEA solutions. The observed sharp decrease in conductance demonstrates the possibility of realizing highly sensitive, label-free SWNT-FET-based tumor sensors.

Keywords: TUMOR MARKERS; CARBON NANOTUBES; FIELD EFFECT TRANSISTORS

Document Type: Research article

DOI: 10.1166/jnn.2006.043