Zinc Phthalocyanine/Magnetic Fluid Complex: A Promising Dual Nanostructured System for Cancer Treatment

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Abstract:

In this study we evaluated the photophysical, photochemical properties of the zinc phthalocyanine/magnetic fluid (ZnPC/MF)complex in liposomal medium. As a result of the present investigation we propose the liposome-encapsulated ZnPC/MF complex as a very promising nanostructured device for cancer treatment. The spectroscopy characterization and the in vitro dark toxicity of both ZnPC and ZnPC/MF complex in Hank's and in liposomal medium are reported. Our findings revealed that the spectroscopic properties of the ZnPC associated or not with MF presented little differences and are very close to what one expects from an ideal photosensitizer compound. Indeed, the ZnPC/MF complex in liposomal medium presented lower dark toxicity compared to the ZnPC/MF complex in Hank's, strongly supporting the use of the former for cancer treatment.

Keywords: HYPERTHERMIA; MAGNETIC FLUID; NANOBIOTECHNOLOGY; PHOTODYNAMIC THERAPY; ZINC PHTHALOCYANINE

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2006.512

Publication date: August 1, 2006

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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