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Single Molecule Fluorescence Control for Nanotechnology

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Abstract:

Nanoscience and nanotechnology are providing fresh approaches to engineer materials with practical applications such as molecular-sized therapeutic and diagnostic devices, drug delivery vehicles, environmental sensors, high-rate manufacturing platforms, and self-assembling nanomachines. In many cases, researchers are mimicking biological systems that easily achieve molecular scale control through directed self-assembly. In parallel, a revolution has occurred in the basic sciences, which utilizes recent advances in fluorescence microscopy to achieve single molecule detection capability. The future will see a merger of these two separate research thrusts, as single molecule detection will afford optimal control over the assembly and performance of individual nanoscale devices.

Keywords: CONFORMATIONAL CHANGE; FLUORESCENCE MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; FRET; NUCLEIC ACID NANOSCIENCE

Document Type: Review Article

DOI: http://dx.doi.org/10.1166/jnn.2005.505

Publication date: December 1, 2005

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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