Specific Binding of Dacarbazine to DNA Bases and Oligonucleotides Based on Gold Nanoparticles

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Abstract:

We studied the specific binding of an anticancer drug, dacarbazine (DTIC), to DNA bases and oligonucleotides attached to gold nanoparticles by using electrochemical methods, and the results indicate that the presence of gold nanoparticles could facilitate the binding of dacarbazine to specific DNA bases and remarkably enhance the relative detection sensitivity. The results of the study on interaction of dacarbazine with oligonucleotides also illustrate that dacarbazine could recognize some specific sequence in DNA chain and sensitively detect single-base mismatch in DNA helix.

Keywords: ELECTROCHEMISTRY; NANOPARTICLES; OLIGONUCLEOTIDES; SINGLE-BASE MISMATCH

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2005.216

Publication date: August 1, 2005

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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