Micro- and Nanoscale Modification of Poly(2-hydroxyethyl methacrylate) Hydrogels by AFM Lithography and Nanoparticle Incorporation

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Abstract:

Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels are widely used as biomaterials. Due to their unique combination ofbiocompatibility and good mechanical properties, they have potential as scaf-folds for tissue engineering applications. To this purpose, topographic and chemical patterning at the nano-to the mesoscale is crucial in order to favor and to characterize cell adhesion and proliferation. Here we report the characterization ofas-prepared and patterned PHEMA hydrogels, produced by conventional radical polymerization in water and dimethylformamide. We have obtained chemical and morphological micro- and nanoscale patterning by atomic force microscopy based lithography. We also demonstrate that it is possible to incorporate carbon nanoparticles in the hydrogel matrix by supersonic cluster beam deposition.

Keywords: ATOMIC FORCE MICROSCOPY; HYDROGEL; NANOLITHO-GRAPHY; NANOSTRUCTURED MATERIALS; PATTERNING; TISSUE ENGINEERING

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2005.061

Publication date: March 1, 2005

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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