Micro- and Nanoscale Modification of Poly(2-hydroxyethyl methacrylate) Hydrogels by AFM Lithography and Nanoparticle Incorporation

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Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels are widely used as biomaterials. Due to their unique combination ofbiocompatibility and good mechanical properties, they have potential as scaf-folds for tissue engineering applications. To this purpose, topographic and chemical patterning at the nano-to the mesoscale is crucial in order to favor and to characterize cell adhesion and proliferation. Here we report the characterization ofas-prepared and patterned PHEMA hydrogels, produced by conventional radical polymerization in water and dimethylformamide. We have obtained chemical and morphological micro- and nanoscale patterning by atomic force microscopy based lithography. We also demonstrate that it is possible to incorporate carbon nanoparticles in the hydrogel matrix by supersonic cluster beam deposition.


Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2005.061

Publication date: March 1, 2005

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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