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Silver Growth on Micropatterned DNA Chips: Effect of Growth Conditions and Morphologyon I–V Behavior

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An approach to the design of DNA-based electronics is presented, in which standard microfabrication processes are integrated with lithographic patterning of single-stranded oligonucleotides followed by hybridization to gold-labeled, complementary oligonucleotides and subsequent silver enhancement for signal amplification. The resulting bioinorganic devices demonstrate micronsized geometric features, very little non-specific silver growth, a distinct silver morphology in the patterned region, and a 109-fold increase in conductivity across an electrode gap when compared with control devices. This approach may prove useful for the fabrication of high fidelity, high-density arrays for DNA-based biosensing applications.


Document Type: Research Article


Publication date: 2005-03-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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