Silver Growth on Micropatterned DNA Chips: Effect of Growth Conditions and Morphologyon I–V Behavior
Abstract:An approach to the design of DNA-based electronics is presented, in which standard microfabrication processes are integrated with lithographic patterning of single-stranded oligonucleotides followed by hybridization to gold-labeled, complementary oligonucleotides and subsequent silver enhancement for signal amplification. The resulting bioinorganic devices demonstrate micronsized geometric features, very little non-specific silver growth, a distinct silver morphology in the patterned region, and a 109-fold increase in conductivity across an electrode gap when compared with control devices. This approach may prove useful for the fabrication of high fidelity, high-density arrays for DNA-based biosensing applications.
Document Type: Research Article
Publication date: 2005-03-01
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