Novel Transducers for Nano-optical Biosensor Chips Based on Biological and Synthetic Polymers with Analyte-Dependent Swelling/Shrinking Behavior
Abstract:Analyte-dependent swelling/shrinking properties of ultrathin polymer layers are an appropriate means for the detection of various analytes. Optical metal nanoclusters can be used to determine the change of the layer´s thickness, which is shown by a change in the color of the chip. By using different cross-linking agents and different polymers (biological or artificial as well) it was possible to design various sensitive layers showing different swelling/shrinking behaviors. Sensitivity on various analytes could be observed, since the different types of polymers employed differed in structure, functional groups, or biorecognitive properties.
Document Type: Research Article
Publication date: January 1, 2004
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