Novel Transducers for Nano-optical Biosensor Chips Based on Biological and Synthetic Polymers with Analyte-Dependent Swelling/Shrinking Behavior

Authors: M. Lepek; F. Pittner

Source: Journal of Nanoscience and Nanotechnology, Volume 4, Numbers 1-2, January 2004 , pp. 106-114(9)

Publisher: American Scientific Publishers

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Abstract:

Analyte-dependent swelling/shrinking properties of ultrathin polymer layers are an appropriate means for the detection of various analytes. Optical metal nanoclusters can be used to determine the change of the layer´s thickness, which is shown by a change in the color of the chip. By using different cross-linking agents and different polymers (biological or artificial as well) it was possible to design various sensitive layers showing different swelling/shrinking behaviors. Sensitivity on various analytes could be observed, since the different types of polymers employed differed in structure, functional groups, or biorecognitive properties.

Keywords: NANOOPTICAL BIOSENSOR CHIPS; DESIGNED TRANSDUCER POLYMERS; METAL NANOCLUSTERS; THIN-FILM TECHNOLOGY; ANALYTE-DEPENDENT SWELLING POLYMERS

Document Type: Research article

DOI: http://dx.doi.org/10.1166/jnn.2004.230

Publication date: 2004-01-01

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Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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