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Synthesis and Characterization of Silica-Embedded Iron Oxide Nanoparticles for Magnetic Resonance Imaging

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Abstract:

In this communication, a conceptually new approach to the delivery of magnetic resonance imaging (MRI) contrast agents is presented. Our experiments demonstrate the feasibility of using silica-embedded iron oxide nanoparticles as contrast agents in magnetic resonance imaging, where a reduction in signal intensity (increased contrast) in the T2-weighted images is observed. The surface of these particles can be chemically modified by attachment of polyethylene glycol molecules, which are found to reduce nonspecific protein binding. The design of the nanoparticle is universal and flexible and allows for facile addition or interchange of its active components (i.e., MRI contrast agents and targeting moiety) with photodynamic dyes.

Keywords: CONTRAST AGENTS; IRON OXIDE; MRI; NANOPARTICLES; SILICA

Document Type: Short Communication

DOI: http://dx.doi.org/10.1166/jnn.2004.074

Publication date: January 1, 2004

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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