Authors: Rainer H. Müller; Cornelia M. Keck

Source: Journal of Nanoscience and Nanotechnology, Volume 4, Number 5, October 2004 , pp. 471-483(13)

Publisher: American Scientific Publishers

Abstract:

Delivery of drugs to the brain is still a major challenge. Successful delivery across the bloodbrain barrier has only been achieved in some cases, e.g., using pro-drugs. The review describes the delivery to the brain using nanoparticulate drug carriers in combination with the novel targeting principle of "differential protein adsorption" (PathFinder^® technology). The PathFinder technology exploits proteins in the blood which adsorb onto the surface of intravenously injected carriers for targeting. Apolipoprotein E is the targeting moiety for the delivery of particles to the endothelials of the blood-brain barrier. To reach therapeutic drug level in the brain, nanoparticulate drug carriers with sufficiently high loading capacity are reviewed, including drug nanocrystals (nanosuspensions), lipid drug conjugate (LDC) nanoparticles and lipid nanoparticles (solid lipid nanoparticles–SLN, nanostructured lipid carriers–NLC). The features are described, including regulatory aspects and large scale production.

Keywords: TARGETING; BRAIN DELIVERY; DRUG NANOCRYSTALS; NANOSUSPENSIONS; SOLID LIPID NANOPARTICLES; SLN; NANOSTRUCTURED LIPID CARRIERS; NLC; LARGE SCALE PRODUCTION

Document Type: Review article

DOI: http://dx.doi.org/10.1166/jnn.2004.078

Publication date: 2004-10-01

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• Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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