Efficacy of Lytic Peptide-Bound Magnetite Nanoparticles in Destroying Breast Cancer Cells

Authors: Challa S.S.R. Kumar; Carola Leuschner; E.E. Doomes; Larry Henry; Martha Juban; Josef Hormes

Source: Journal of Nanoscience and Nanotechnology, Volume 4, Number 3, March 2004 , pp. 245-249(5)

Publisher: American Scientific Publishers

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Abstract:

A 23-amino-acid synthetic lytic peptide (Hecate) was covalently linked to magnetite nanoparticles and the lytic peptide-bound nanoparticles were characterized by X-ray absorption near-edge structure spectroscopy, transmission electron microscopy, and electron diffraction. Investigation of magnetic properties with a superconducting quantum interference device (SQUID) magnetometer has shown a reduction in the saturation magnetization (M_s) of magnetite nanoparticles after binding with lytic peptide. An in vitro cell culture assay with breast cancer cell lines MDA-MB-435S revealed that the lytic peptide-bound magnetite nanoparticles were therapeutically active.

Keywords: MAGNETITE NANOPARTICLE; LYTIC PEPTIDE; BREAST CANCER CELLS

Document Type: Research article

DOI: 10.1166/jnn.2004.085

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