@article {Challa:1 March 2004:1533-4880:245, author = "Challa S.S.R. Kumar", author = "Carola Leuschner", author = "E.E. Doomes", author = "Larry Henry", author = "Martha Juban", author = "Josef Hormes", title = "Efficacy of Lytic Peptide-Bound Magnetite Nanoparticles in Destroying Breast Cancer Cells", journal = "Journal of Nanoscience and Nanotechnology", volume = "4", year = "1 March 2004", abstract = "A 23-amino-acid synthetic lytic peptide (Hecate) was covalently linked to magnetite nanoparticles and the lytic peptide-bound nanoparticles were characterized by X-ray absorption near-edge structure spectroscopy, transmission electron microscopy, and electron diffraction. Investigation of magnetic properties with a superconducting quantum interference device (SQUID) magnetometer has shown a reduction in the saturation magnetization (Ms) of magnetite nanoparticles after binding with lytic peptide. An in vitro cell culture assay with breast cancer cell lines MDA-MB-435S revealed that the lytic peptide-bound magnetite nanoparticles were therapeutically active.", pages = "245-249(5)", url = "http://www.ingentaconnect.com/content/asp/jnn/2004/00000004/00000003/art00005" doi = "doi:10.1166/jnn.2004.085" }