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A Ligand-Gated Ion-Channel Mimetic Nanopore Membrane with an On-Board Transmembrane Microbattery

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Abstract:

We have been investigating synthetic nanopore membranes that mimic the function of ligand-gated ion channels. We showed previously that the transmembrane ion current in a hydrophobic alumina nanopore membrane can be switched from an "off" state to an "on" state by exposure of the membrane to hydrophobic ionic surfactants. In these prior experiments, external electrodes and an external power supply were used to drive the ion current when the membrane was in its "on" state. In biological channels there are no electrodes, and the ion current is driven by an electrochemical potential difference across the cell membrane. In this article we mimic this function of the ligand-gated ion channel by applying a porous battery cathode film to one face of the hydrophobic alumina membrane and a porous battery anode film to the other face. Hence, in analogy to the naturally occurring channel case, we have a membrane with a built in electrochemical potential difference across the membrane. We show here that in the absence of the ligand (again, a hydrophobic ionic surfactant), the membrane is in its "off" state, and the electrochemical potential difference cannot be utilized to drive a transmembrane ion current. In contrast, when the ligand is detected, the membrane switches to its "on" state and the transmembrane battery discharges, producing a corresponding transmembrane ion current.

Keywords: MICROBATTERY; NANOPORE MEMBRANES; SYNTHETIC ION-CHANNELS

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2004.031

Publication date: March 1, 2004

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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