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Covalent Attachment of Gold Nanoparticles to DNA Templates

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Abstract:

Functionalized gold nanoparticles have been covalently bound to internal, modified sites on double-stranded DNA. Gold nanoparticles coated with mercaptosuccinic acid or thioctic acid were bound to amino-modified thymine bases on double-stranded DNA. Visible absorption spectra, gel electrophoresis, and atomic force microscopy were used to analyze the products. Thiol groups were added to one end of the gold/nanoparticle product, which was then attached to a gold surface. This method has the potential to allow controlled placement of particles with subnanometer precision and to allow attachment of the product to fixed contacts for nanodevice fabrication.

Keywords: ABSORPTION SPECTROSCOPY; ATOMIC FORCE MICROSCOPY; DNA TEMPLATES; GEL ELECTROPHORESIS; GOLD NANOPARTICLES; OLIGONUCLEOTIDES

Document Type: Research Article

DOI: https://doi.org/10.1166/jnn.2002.110

Affiliations: 1: Center for Engineering Science Advanced Research, Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA 2: Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA 3: Center for Engineering Science Advanced Research, Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA

Publication date: 2002-07-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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