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Operation Kinetics of a DNA-Based Molecular Switch

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Abstract:

The influence of temperature variation, salt concentration, and pH on the operation kinetics of a simple DNA-based molecular switch is investigated. The device shows robust behavior over a wide range of temperatures, pH, and salt concentrations. In particular, the device operates well under physiological conditions. The experimental data can be qualitatively understood in terms of the influence temperature, salt concentration, and pH have on DNA strand interactions.

Keywords: DNA; MOLECULAR MACHINES; SELF-ASSEMBLY

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jnn.2002.122

Affiliations: 1: a Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey, USA 2: Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey, USA

Publication date: July 1, 2002

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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