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Analytical Computation of Electric Field for Onset of Electroporation

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Abstract:

In the present study, the electric field (E-field) required to electroporate a living cell has been analytically evaluated using two electrical equivalent circuits of the cell. The analysis of the electroporation is based on the transmembrane potential (TMP), induced due to applied electric field. The implication of the analytical model has been interpreted in terms of understanding the influence of cell size, pulse duration and electrophysical conditions of cell (normal and cancer cells) on the E-field parameters (strength and duration) required for electroporation. In order to validate the electrical circuit model of the cell, the analytical results were compared with the reported literature results. It has been found that lower field is required to electroporate larger sized cells as compared to the smaller sized cells. Electroporation occurs at low electric field strength (∼2 KV/cm) for the pulse of tens of microsecond to millisecond duration. In contrast, electroporation occurs at higher field strength (∼102 KV/cm), for nanosecond pulse. For similar combination of field strength and pulse duration, selective killing of cancerous cells is possible, without disrupting the normal cell membrane structure.

Keywords: ELECTRIC FIELD; ELECTROPORATION; LIVING CELL

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jctn.2012.2008

Publication date: January 1, 2012

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  • Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
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