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Prefoldin: A Nano Actuator for Carrying the Various Size Nano Drugs

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Abstract:

A molecular dynamics study for characterization of Prefoldin based bio nano actuator is presented in this paper. Prefoldin is a hexameric molecular chaperone complex in the eukaryotic cytosol and archaea with a jellyfish-like structure containing six long coiled-coil tentacles and a large central cavity. Prefoldin captures protein folding intermediates or unfolded polypeptides and transfer them to group II chaperonins for facilitated folding. Each coiled coil was highly flexible, enabling it to widen its central cavity and capture various nonnative proteins. In this paper, we are studying the development of Prefoldin as nano actuator in bio nano robotic systems. Design hypothesis and preliminary computational results are also presented. In this paper, we are focusing on the properties of Prefoldin to change its conformation depending on the temperature of environment. Our results show how archaeal Prefoldin may be well adapted to interacting with many different substrates.

Keywords: GROMACS; MOLECULAR CHAPERONE; MOLECULAR DYNAMICS; PREFOLDIN NANO ACTUATOR

Document Type: Research Article

DOI: https://doi.org/10.1166/jctn.2011.1929

Publication date: 2011-10-01

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  • Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
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