Authors: Ghaffari, A.; Shokuhfar, A.; Ghasemi, R. Hasanzadeh

Source: Journal of Computational and Theoretical Nanoscience, Volume 8, Number 10, October 2011 , pp. 2078-2086(9)

Publisher: American Scientific Publishers

Abstract:

A molecular dynamics study for characterization of Prefoldin based bio nano actuator is presented in this paper. Prefoldin is a hexameric molecular chaperone complex in the eukaryotic cytosol and archaea with a jellyfish-like structure containing six long coiled-coil tentacles and a large central cavity. Prefoldin captures protein folding intermediates or unfolded polypeptides and transfer them to group II chaperonins for facilitated folding. Each coiled coil was highly flexible, enabling it to widen its central cavity and capture various nonnative proteins. In this paper, we are studying the development of Prefoldin as nano actuator in bio nano robotic systems. Design hypothesis and preliminary computational results are also presented. In this paper, we are focusing on the properties of Prefoldin to change its conformation depending on the temperature of environment. Our results show how archaeal Prefoldin may be well adapted to interacting with many different substrates.

Keywords: MOLECULAR CHAPERONE; PREFOLDIN NANO ACTUATOR; MOLECULAR DYNAMICS; GROMACS

Document Type: Research article

DOI: http://dx.doi.org/10.1166/jctn.2011.1929

Publication date: 2011-10-01

More about this publication?

• Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Physical & Theoretical Chemistry ,  Materials & Manufacturing ,  Genetics
• By this author: Ghaffari, A. ;  Shokuhfar, A. ;  Ghasemi, R. Hasanzadeh

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers