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Biocatalytic Paradigms for Unconventional Information Processing

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Here we present an analysis of a new unconventional computing paradigm based on chemical reactions catalyzed by enzymes. This distinct concept hinges on the specificity of biocatalysts and selects chemical changes as information bits. The present review unveils the development of enzyme-based computing—from single Enzyme Logic Gates performing Boolean operations to some examples of concatenated networks. Inputs are defined as chemicals or as the biocatalyst, while the system output is read via optical or electrochemical means. The coupling of enzyme logic gates to signal-responsive interfaces is also developed, thus providing an approach to integrate enzymatic biocomputing into existing technology.
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Document Type: Review Article

Publication date: 2011-03-01

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  • Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
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