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Monte-Carlo Simulation on Gold Nanoshells Enhanced Laser Interstitial Thermal Therapy on Target Tumor

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Abstract:

The laser-induced interstitial thermal therapy (LITT) is emerging as a very promising way for minimally invasive treatment on tumor. To realize a highly efficient heating, the gold nanoshells were recently identified as most useful materials to enhance thermal energy deposition of laser in target tissues. However, there is currently a strong lack of understanding the laser energy distribution and the transient temperature field in the tissues due to addition of nanoshells which would seriously impede successful operation of a LITT surgery. This paper is dedicated to present a theoretical modeling on the optical and temperature fields during gold nanoshells enhanced hyperthermia through combining the Monte-Carlo simulation strategy and the Pennes bioheat transfer equation. Effects of size, concentration of the nanoshells to the heating behaviors were evaluated through parametric studies and important conclusions were obtained. The method as developed in the paper would serve well for future treatment planning for the nanoshells enhanced LITT on target tumor tissues.

Keywords: BIOHEAT TRANSFER; GOLD PARTICLE; LASER-INDUCED THERMAL THERAPY; MONTE-CARLO SIMULATION; NANO HYPERTHERMIA; NANOSHELL

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jctn.2010.1448

Publication date: June 1, 2010

More about this publication?
  • Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
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