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Computational Modeling of the Collective Stochastic Motion of Kinesin Nano Motors

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Abstract:

The collective traffic of a number of kinesin protein motors, executing an asymmetric hand-over-hand motion on the microtubule track within the stochastically fluctuating intracellular medium is simulated via Brownian dynamics. The kinesin heads experience a flashing ratchet potential that models their interaction with the microtubule track, and the random hydrolysis of the ATP molecule, and a bistable potential that correlates the motion of individual heads. The overall stochastic medium within the cell is represented by white noise. Our simulation provides the average directed velocity and the of the current of kinesins along the microtubule. It is shown that beyond a certain density of kinesins, the average velocity and current undergo a notable decrease.

Keywords: ASYMMETRIC HAND-OVER-HAND MOTION; COLLECTIVE TRAFFIC; COMPUTATIONAL MODELING; FLASHING RATCHET POTENTIAL; KINESIN MOLECULAR MOTORS; LANGEVIN DYNAMICS

Document Type: Research Article

DOI: https://doi.org/10.1166/jctn.2010.1338

Publication date: 2010-01-01

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  • Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
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