Computational Modeling of the Collective Stochastic Motion of Kinesin Nano Motors
Abstract:The collective traffic of a number of kinesin protein motors, executing an asymmetric hand-over-hand motion on the microtubule track within the stochastically fluctuating intracellular medium is simulated via Brownian dynamics. The kinesin heads experience a flashing ratchet potential that models their interaction with the microtubule track, and the random hydrolysis of the ATP molecule, and a bistable potential that correlates the motion of individual heads. The overall stochastic medium within the cell is represented by white noise. Our simulation provides the average directed velocity and the of the current of kinesins along the microtubule. It is shown that beyond a certain density of kinesins, the average velocity and current undergo a notable decrease.
Document Type: Research Article
Publication date: 2010-01-01
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