Skip to main content

Modelling the Bioenergetics of Halobacterium Salinarum with Petri Nets

Buy Article:

$105.00 plus tax (Refund Policy)

We present a Petri net model for the membrane potential regulated phosphorylation in Halobacterium salinarum which allows for the analysis of the relationships between the membrane potential and the bioenergetic processes. The membrane potential generating processes are proton extrusion by bacteriorhodopsin and the complexes in the respiratory chain. The light driven pump halorhodopsin also enhances the membrane potential by moving negatively charged chloride ions inside the cell. We consider two cases for the sodium-proton antiporter: electro-neutral and electrogenic, and analysis is made for each. The model is validated by determining the dynamic properties of the Petri net and performing structural and invariant analysis. T-invariant analysis shows that bacteriorhodopsin and respiration can independently drive phosphorylation. On the other hand, T-invariant analysis also shows that the chloride pump halorhodopsin is not able to independently drive photo-phosphorylation. Furthermore, results on T-invariant analysis agree with experimental evidence that movement of sodium and potassium ions are charged balanced. Computation of the Abstract Dependent Transition Sets (ADT-sets) of the network yield exactly the basic components (or modules) consisting of the respiratory chain, bacteriorhodopsin, halorhodopsin, potassium uniport, the antiport and ATP synthesis/hydrolysis.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Publication date: 01 August 2009

More about this publication?
  • Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more