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Double-Walled Carbon Nanotubes as Nanosyringes

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Abstract:

Functionalized nanoparticles and nanotubes may be able to target specific cells, become ingested and then release their contents in response to a chemical trigger. An alternative delivery mechanism, which may offer advantages in drug delivery is the use of a nanosyringe which pierces the cell membrane and injects molecules such as DNA or anticancer drugs directly into the cell. Here, we propose the use of double-walled carbon nanotubes as nanosyringes. By way of illustration we investigate the suction and expulsion mechanisms, using elementary mechanics and applied mathematical modeling techniques, for both a C60 fullerene and the anticancer drug cisplatin, but similar calculations can be undertaken for any molecule. Some specific guidelines are formulated to assist medical scientists to facilitate nanosyringe development.

Keywords: CISPLATIN; FULLERENE; LOADING/UNLOADING; MECHANICS; NANOSYRINGE

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jctn.2008.1112

Publication date: November 1, 2008

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  • Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
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