Authors: Martin, A.R.; Finlay, W.H.

Source: Journal of Computational and Theoretical Nanoscience, Volume 5, Number 10, October 2008 , pp. 2067-2070(4)

Publisher: American Scientific Publishers

Abstract:

In this communication, the magnetic torque acting on a high aspect ratio aerosol particle loaded with magnetite nanoparticles is estimated and compared to the aerodynamic torque arising from shear in the entraining airflow. For a flow velocity gradient typical of that found in the small airways of the lung, for particle aspect ratios of up to 100, and for modest magnetic field strength, the magnetic torque is expected to exceed the aerodynamic torque by at least one order of magnitude for all but very low levels of loading. As a result, loading high aspect ratio aerosol particles with magnetite nanoparticles is seen as a viable means for achieving noninvasive control of particle orientations within the lung. Such control could be used to enhance deposition of inhaled drug particles at targeted locations.

Keywords: RESPIRATORY DRUG DELIVERY; MAGNETIC DRUG TARGETING; COMPOSITE PARTICLE MAGNETIZATION; MAGNETIZATION ANISOTROPY; AEROSOLS; IRON OXIDE NANOPARTICLES; SUPERPARAMAGNETIC NANOPARTICLES

Document Type: Short communication

DOI: http://dx.doi.org/10.1166/jctn.2008.1009

Publication date: 2008-10-01

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• Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
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