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Effects of Two Types of Non-Digestible Carbohydrates on Energy Metabolism in Mice

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Metabolic syndrome is the name for a group of risk factors that raises the risk of arteriosclerosis due to high blood glucose concentrations, blood pressure, lipid metabolism, and other abnormalities caused by obesity. Dietary habits influence the metabolic syndrome. Dietary fibers are important for the preventing metabolic syndrome. We studied the effects of indigestible saccharides on energy metabolism for the prevention of metabolic syndrome. Six-week-old male C57BL/6 mice were fed a high fat diet for 9 weeks to induce obesity. They were divided into the following groups: 2% cellulose-high fat diet (CE), 2% colestimide-high fat diet (CS), 2% chitosan-high fat diet (CH2), 4% chitosan-high fat diet (CH4), 2% inulin-high fat diet (IN2), and 4% inulin-high fat diet (IN4). At week 5 after the grouping, oxygen consumption and respiratory quotient were measured. Blood was collected from tails to measure fasting blood glucose and insulin levels. Somatic fat mass was measured using an X-ray computed tomography scanner. At week 13, whole blood was collected to determine the various serum lipid levels. Body weight gain, visceral fat, and epididymal white adipose tissue mass were significantly lower in IDS groups than in the CE group. Cumulative oxygen consumption was significantly higher in CH4 and IN4 groups than in the CE group. Respiratory quotient values showed no significant differences among IDS groups. Fasting blood glucose level was tended to be lower in the IDS groups than in the CE group at weeks 9 and 12. Thus, energy metabolism was elevated in CH4 and IN4 groups, indicating that the type and amount of indigestible saccharide is important. The levels of serum lipids and total cholesterol tended to be lower in CS and CH groups than in the CE group while those of total bile acids tended to be elevated in CS and CH4 groups compared to the CE group. The elevated energy metabolism and decreased fasting blood glucose levels demonstrate that indigestible saccharides prevent metabolic syndrome.
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Keywords: CHITOSAN; ENERGY EXPENDITURE; HIGH-FAT DIET; HOMA-IR; INSULIN; INULIN; MICE; OBESITY; SERUM GLUCOSE

Document Type: Research Article

Publication date: 01 September 2014

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  • Journal of Chitin and Chitosan Science (JCC) is an international peer-reviewed journal that covers all aspects of chitin and chitosan based biomaterials and their derivatives, their sources, commercial production, processing, spectroscopic characterization, biochemistry, biology, enzymology, ecology, chemical and physico-chemical properties, biological activities, medical and biomedical applications such as drug delivery systems, gene delivery, pharmaceuticals, tissue engineering, wound healing agents, antimicrobial activities, biotextiles, biocatalysis, food science, agriculture, water purification, environment, and other areas of life sciences and materials science.
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