Biodegradable and Thermosensitive Monomethoxy Poly(ethylene glycol)–Poly(lactic acid) Hydrogel as a Barrier for Prevention of Post-Operative Abdominal Adhesion
Post-operative peritoneal adhesions are serious consequences of abdominal or pelvic surgery and cause severe bowel obstruction, chronic pelvic pain and infertility. In this study, a novel nano-hydrogel system based on a monomethoxy poly(ethylene glycol)–poly(lactic acid) (MPEG–PLA) di-block copolymer was studied for its ability to prevent abdominal adhesion in rats. The MPEG–PLA hydrogel at a concentration of 40% (w/v) was injected and was able to adhere to defect sites at body temperature. The ability of the hydrogel to inhibit adhesion of post-operative tissues was evaluated by utilizing a rat model of abdominal sidewall-cecum abrasion. It was possible to heal wounded tissue through regeneration of neo-peritoneal tissues ten days after surgery. Our data showed that this hydrogel system is equally as effective as current commercialized anti-adhesive products.
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Document Type: Research Article
Publication date: 2014-03-01
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