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Biodegradable and Thermosensitive Monomethoxy Poly(ethylene glycol)–Poly(lactic acid) Hydrogel as a Barrier for Prevention of Post-Operative Abdominal Adhesion

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Post-operative peritoneal adhesions are serious consequences of abdominal or pelvic surgery and cause severe bowel obstruction, chronic pelvic pain and infertility. In this study, a novel nano-hydrogel system based on a monomethoxy poly(ethylene glycol)–poly(lactic acid) (MPEG–PLA) di-block copolymer was studied for its ability to prevent abdominal adhesion in rats. The MPEG–PLA hydrogel at a concentration of 40% (w/v) was injected and was able to adhere to defect sites at body temperature. The ability of the hydrogel to inhibit adhesion of post-operative tissues was evaluated by utilizing a rat model of abdominal sidewall-cecum abrasion. It was possible to heal wounded tissue through regeneration of neo-peritoneal tissues ten days after surgery. Our data showed that this hydrogel system is equally as effective as current commercialized anti-adhesive products.
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Keywords: ADHESION PREVENTION; BARRIERS; MPEG– PLA HYDROGEL; POST-OPERATIVE ADHESION

Document Type: Research Article

Publication date: 01 March 2014

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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