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Water-Soluble Pristine Fullerenes C60 Increase the Specific Conductivity and Capacity of Lipid Model Membrane and form the Channels in Cellular Plasma Membrane

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Abstract:

The aim of the present work was the investigation of the interaction of water-soluble pristine fullerenes C60 with bimolecular lipid model membrane (BLM) and cellular plasma membrane (PM). The findings demonstrate that the fullerenes C60 at low concentrations, namely in the concentration range of 1.0 × 10−4–1.0 mg·ml−1, are preferentially incorporated into the hydrophobic region of BLM, increasing, thus, its specific conductivity and specific capacity. Furthermore, upon interaction of fullerenes C60 with PM, pores or other type of local defects are formed, which are wide enough in order to permit the passage of water molecules across the cell membrane resulting to the externalization of phosphatidylserine from the inner to the outer PM leaflet.

Keywords: CELLULAR PLASMA MEMBRANE; CONDUCTIVITY; FULLERENES; LIPID MODEL MEMBRANE; PHOSPHATIDYLSERINE; SPECIFIC CAPACITY

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jbn.2012.1404

Publication date: June 1, 2012

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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