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Exposure, Uptake, Distribution and Toxicity of Nanomaterials in Humans

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Abstract:

The last decade has witnessed an unprecedented explosion in nanotechnology to take advantage of the unique physicochemical properties that emerge at the nanoscale including quantum effects. However, the excitement generated by new applications of nanotechnology in products has not been matched by a parallel appreciation or understanding of their potential toxic effects in humans and the wider ecology. This review draws some parallels to what we already know about the toxicity of particles in the workplace and in association with air pollution, and then discusses what is known about the toxicology of nanomaterials in mammals including humans. The review identifies substantial gaps in knowledge and makes some recommendations for future research.

Keywords: AIR POLLUTION; CARDIOVASCULAR; CELLULAR UPTAKE; CENTRAL NERVOUS SYSTEM; HEPATIC; NANOMATERIALS; NANOPARTICLE; PULMONARY; REACTIVE OXYGEN; RENAL; TOXICOLOGY

Document Type: Review Article

DOI: http://dx.doi.org/10.1166/jbn.2010.1098

Publication date: February 1, 2010

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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