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Novel Thermosensitive Nano-Micelles from Triblock Copolymer for Drug Delivery

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Abstract:

Novel thermosensitive nano-micelles, based on Poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA), as carriers for drug delivery were researched. The critical micelle concentration of the copolymer in aqueous solution was determined to be 2.34 g/ml by fluorescence spectroscopy using pyrene as a fluorescence probe. The lower critical solution temperature (LCST) of the copolymer was measured in distilled water by optical transmittance, and the LCST was varied from 35 to 55 °C depending on polymer concentration. Acetaminophen as a model drug was loaded in nano-micelles by solvent evaporation method. In vitro acetaminophen release from micelles showed a sustained modality compared with the free drug as a control, and an obviously high release rate when temperature was increased above LCST. The studies showed that nano-micelles made from PLGA-PEG-PLGA could be ideal candidate carriers for tumor-special drug delivery.

Keywords: LCST; NANO-MICELLES; PLGA-PEG-PLGA; THERMOSENSITIVE; TUMOR-SPECIAL DRUG DELIVERY

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jbn.2009.1036

Publication date: June 1, 2009

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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