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Challenges and Potential for RNA Nanoparticles (RNPs)

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Abstract:

The current research of our group focuses on delivery of oligonucleotides and gene vaccines targeted against infectious disease and cancer. Recently we reported a strategy for associating DNA to gold via protamine delivery enhancing material which here we suggest might be applicable to RNA and to other nanoparticles. An important new modality for such RNA based nanoparticles (RNPs) is the myriad of genes now known to undergo alternative splicing. Here we will review some important issues for the binding, stabilization and delivery of RNA, particularly splice-site switching oligomers (SSOs) via these RNPs in order to achieve selective molecular therapeutic effects and unlocktheir potential as chemotherapeutic agents.

Keywords: DELIVERY; NANOPARTICLES (NPS); POLYAMIDOAMINE (PAMAM); PROTAMINE; SIRNA; SPLICE-SITE SWITCHING OLIGOMER (SSO)

Document Type: Review Article

DOI: http://dx.doi.org/10.1166/jbn.2009.1005

Publication date: February 1, 2009

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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