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Multilayer Implant with Triple Drug Releasing Properties

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Abstract:

Tissue repair and regeneration is a multistep process. Several drug releasing materials have been developed to help the healing process of tissues after damage. Most of these are loaded with a single agent. In the current study, we developed a composite loaded with three drugs to enhance the control of the healing process of bone. The biodegradable composite comprised two anti-inflammatory agents in a nanofibrous and macrofibrous matrix and bisphosphonates in a solid membrane. Three different multilayers were studied and the release of the agents was compared. Statistical analysis revealed a close correlation of releases between the multilayer implants except the release from the solid membrane. The first phase of release was from the nanofibrous component, followed by a more steady release from the macrofibers and a later release of the agent from the solid membrane. On the basis of these results a developed multilayer composite, releasing different agents, could be adapted for bone repair and regeneration applications.

Keywords: COMPOSITE; ELECTROSPINNING; IMPLANT; INTELLIGENT BIOMATERIAL; MULTICOMPONENT; NANOFIBERS

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jbn.2008.337

Publication date: September 1, 2008

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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