Nanoemulsions as Vehicle for Topical 8-Methoxypsoralen Delivery

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Abstract:

This work describes preparation, characterization and properties of nanoemulsion formulations as drug carrier systems for topical application of 8-methoxypsoralen (8-MOP). The lipid emulsions were prepared from soy bean oil, as oil phase, different mixtures of phospholipids as emulsifiers (soy phosphatidylcholine or hydrogenated soy phosphatidylcholine or soy lecithin), and a mixture water/glycerine as aqueous phase. To characterize the physicochemical properties of the lipid nanoemulsions, average diameter, polydispersity index and Zeta potential were determined. The effects of the nanoemulsion incorporation on the 8-MOP diffusion through and into the skin were investigated in vitro using newborn pig skin. Data showed that 8-MOP was predominantly localized in the different skin layers, with a minimal amount (less than 0.05% of the applied dose) detected in the receptor compartment.

Keywords: 8-METHOXYPSORALEN; NANOEMULSION; NEWBORN PIG SKIN; TOPICAL APPLICATION

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jbn.2008.342

Publication date: September 1, 2008

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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