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Fabrication of a Biomimetic Compound Containing Nano Hydroxyapatite—Demineralised Bone Matrix

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Abstract:

The aim of the present study is to fabricate a biomemitic composite that contains nano hydroxyapatite (nHAp) and Demineralised bone matrix (DBM), and characterize the same for its physico-chemical properties. In the present study, nHAp was prepared using mineralized liquid, a byproduct of glue and gelatin industry, employing wet precipitation methods. DBM was isolated from cattle tibial bones, and a DBM-nHAp composite was prepared. The TEM pictures of nHAp displayed spherical shaped nano particles in the range of 2 to 50 nm. XRD of nHAp is almost identical with the synthetic HAp. FTIR spectrum of the DBM-nHAp composite has shown characteristic peaks of both DBM and HA. The SEM picture of DBM-nHAp has shown coating of DBM on the surface of nHAp crystals with porous nature. As both DBM and nHAp are bio-based materials, the biocompatibility and acceptance of the bone graft by the host tissue is expected to be excellent. As the implant contains both organic and inorganic phases of the bone, with porous nature, the osteoinduction will occur by creeping substitution mechanism, which is a desirable property for an ideal bone graft.

Keywords: BIOMIMETIC COMPOSITE; BONE GRAFT; DEMINERALISED BONE MATRIX; HYDROXYAPATITE

Document Type: Research Article

DOI: https://doi.org/10.1166/jbn.2007.042

Publication date: 2007-12-01

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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