Lipid Nano Spheres (LNSs) for Enhanced Oral Bioavailability of Amphotericin B: Development and Characterization
Abstract:Amphotericin B is the gold standard for the treatment of systemic fungal infections and visceral leishmaniasis. Amphotericin B is not absorbed orally because of its poor aqueous solubility. Amphotericin B loaded Lipid Nano Spheres were prepared to improve its absorption from gastrointestinal tract. Lipid Nano Spheres (LNSs) of mono and triglycerides were prepared in different drug lipid ratios by melt dispersion technique. The influence of process variables like, type and amount of lipids, stirring speed and time were studied. The optimized LNSs were characterized for shape, size and size distribution and entrapment efficiency. The In vitro drug release profile of the LNSs showed approximately 40–50% release in 8 hours. In vivo efficacy was determined in healthy albino rats. After oral administration of the LNSs (33 mg/Kg body wt), the bioavailability was increased by approximately 40 times. The mechanism of enhanced absorption of LNSs is not clear, the possible mode may be the lymphatic uptake of the LNSs by intestinal peyer's patches.
Document Type: Research Article
Publication date: 2007-09-01
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