N-ethylmaleimide-Sensitive Factor is a Right-Handed Molecular Motor

Authors: Cho, Won Jin; Jena, Bhanu P.

Source: Journal of Biomedical Nanotechnology, Volume 3, Number 2, June 2007 , pp. 209-211(3)

Publisher: American Scientific Publishers

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Abstract:

Exposure of t-/v-SNARE complex to the ATPase N-ethylmaleimide-sensitive factor (NSF) and ATP, results in the disassembly of the complex, which can be imaged at near nanometer resolution using AFM. This study shows that t-/v-SNAREs form left-handed supercoils, which are uncoiled by NSF. These results demonstrate for the first time that NSF is a right-handed molecular motor.

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Keywords: CELL SECRETION; MEMBRANE FUSION; NSF; MOLECULAR MOTOR; ATPASE

Document Type: Short communication

DOI: http://dx.doi.org/10.1166/jbn.2007.026

Publication date: 2007-06-01

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Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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