Skip to main content

Biophysical Investigation of Nanoparticle Interactions with Lung Surfactant Model Systems

Buy Article:

$113.00 plus tax (Refund Policy)


The purpose of the study was to investigate the interactions between nanoparticles and artificial lung surfactants using biophysical in vitro methods. Dipalmitoylphosphatidylcholine, the main lipid component of lung surfactant, was used as a model system. The lipid, in combination with extractions of gelatin based nanoparticles, as well as interactions of the nanoparticles in the subphase with the lipid film spread on top, were analyzed by recording surface pressure-area isotherms using a Langmuir trough. The results indicated extractions of nanoparticles alone form monolayers with reduced maximum surface pressures of approximately 10mN/m in magnitude when compared to the lipid films (maximum surface pressures of approximately 50–55 mN/m). Increasing area per molecule values in binary mixtures showed considerable nanoparticle incorporation into the films. Present was a visibly enhanced insertion upon decreasing lipid:nanoparticle ratios and accordingly additional area occupation by the nanoparticles was observed. The high surface pressure values obtained from the isotherms of the binary mixtures indicate the notion that their size dependent incorporation does not destabilize the monolayer film. The study results demonstrated that pulmonary nanoparticle delivery is a possible route of administration. This might help assess possible toxicity related to destabilization of the surfactant film, as well as, help set upper deposition limits for inhalable formulations containing nanoparticles.


Document Type: Research Article


Publication date: October 1, 2006

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more